2023年4月6日 · Rhabdomyosarcoma with prominent fascicular spindle cell or sclerosing features Relatively similar morphology but a genetically and clinically heterogeneous disease, especially in the pediatric population

2018年9月4日 · Three genomic groups have been defined: an infantile subset of spindle cell rhabdomyosarcoma harboring VGLL2 -related gene fusions, a MYOD1 -mutant subset commonly associated with sclerosing...

Rhabdomyosarcoma (RMS) is a rare soft tissue malignancy demonstrating skeletal muscle differentiation. It is classified into four broad categories based on the most recent WHO classification: (1) Alveolar (ARMS), (2) Embryonal (ERMS), (3) Pleomorphic (PRMS), (4) Spindle cell/sclerosing (S-ScRMS) [1].

Spindle cell/sclerosing rhabdomyosarcoma is a rare type of cancer that starts in skeletal muscle tissue, which is responsible for voluntary movements. It can affect people of all ages, but the features of this cancer can vary between children and adults.

Three genomic groups have been defined: an infantile subset of spindle cell rhabdomyosarcoma harboring VGLL2 -related gene fusions, a MYOD1 -mutant subset commonly associated with sclerosing morphology, and a subset lacking recurrent genetic abnormalities.

Spindle cell / sclerosing rhabdomyosarcoma is a variant of rhabdomyosarcoma characterized by spindle-shaped or densely sclerotic tumor cells, often involving genetic rearrangements.

2020年12月11日 · Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a rare rhabdomyosarcomas (RMS) subtype. Especially cases bearing a myogenic differentiation 1 ( MYOD1) mutation are characterized by a high recurrence and …

Three genomic groups have been defined: an infantile subset of spindle cell rhabdomyosarcoma harboring VGLL2-related gene fusions, a MYOD1-mutant subset commonly associated with sclerosing morphology, and a subset lacking recurrent genetic abnormalities.

2017年5月2日 · Rhabdomyosarcoma (RMS) is a rare soft tissue malignancy demonstrating skeletal muscle differentiation. It is classified into four broad categories based on the most recent WHO classification: (1) Alveolar (ARMS), (2) Embryonal (ERMS), (3) Pleomorphic (PRMS), (4) Spindle cell/sclerosing (S-ScRMS) [1].

Sclerosing and spindle cell rhabdomyosarcoma is a rare histologic subtype, designated in the latest WHO classification as a stand-alone pathologic entity. Three genomic groups have been...