Tacalcitol (1,24-dihydroxyvitamin D 3) is a synthetic vitamin D 3 analog. [1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa. It is on the World Health Organization's List of Essential Medicines. [2]

2024年10月5日 · Tacalcitol is used to treat plaque psoriasis - this is the most common type of psoriasis. It is a condition where red scaly patches develop on your skin, called plaques. The most common areas affected are over your elbows and knees, the scalp and the lower part of your back. The patches may vary in size from time to time and can be itchy.

是银屑病的首选外用药，两者都可以较好地改善银屑病皮疹，疗效相似。 而且可以帮助减少激素用量。 在2-6周起效后，可以逐步撤减激素药膏（比如地塞米松、倍他米松）的用量，减少激素大量的皮肤变薄、感染等不良反应。 加用此类药物后，皮损消退后不容易反弹，可以长时间应用，足量足疗程使用更能减少复发。 他卡西醇和 卡泊三醇 一样都是维生素D3衍生物，目前国内有售的卡泊三醇有好几种，而他卡西醇只有 萌尔夫 一种。 两者在治疗银屑病的药理作用和效果基本上是 …

他卡西醇具有抑制表皮细胞增殖作用和诱导细胞分化作用，可用于治疗以银屑病为主的皮肤角化过度异常。 [1] 889.5mg化合物 (Ⅰ)溶于30ml二甲亚砜，加入 叔丁醇 钾 (从0.5g钾制得)，在氩气下于20℃反应30min。 倾入冰水，用乙醚提取。 提取液用水洗，干燥，浓缩。 残物溶于乙醚，在-10℃或以下，将其滴到硼氢化钙和氯化钙在甲醇的溶液中，再在-10℃搅拌1h。 用乙酸水溶液破坏过量的硼氢化钙，然后浓缩，再用二氯甲烷提取。 提取液水洗，干燥，浓缩。 残物溶于二氯 …

Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium. IC50 value: Target: Tacalcitol modulates immunological and inflammatory processes. Tacalcitol induces nerve …

Tacalcitol. Tacalcitol (1α,24-dihydroxyvitamin D 3) differs structurally from calcitriol in that there is a hydroxyl group at the 24 position rather than at the 25 position. Like calcipotriene, it has less hypercalcemic activity than calcitriol.

Tacalcitol is a hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp. It has a role as an antipsoriatic, a vitamin D receptor agonist and an antineoplastic agent. It is a member of D3 vitamins ...

A facile and novel strategy has been developed for synthesis of 24-(R)-hydroxycholesterol, a key intermediate of tacalcitol, starting from 24-dehydrocholesterol in seven steps with 48.2% overall yield and high diastereomer ratio.

Tacalcitol sold under the brand names Curatoderm among others, is a medication used to treat psoriasis, specifically plaque psoriasis. It is applied to the skin once to twice per day. Side effects may include skin rash and high calcium. It is a manufactured vitamin D 3 analog. Tacalcitol was approved for medical use in Japan in 1993.

View tacalcitol information, including dose, uses, side-effects, pregnancy, breast feeding, contra-indications and monitoring requirements.