The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic …

In this review, we highlight the cancer-relevant TNFSF/TNFRSF family members, focusing on the death domain-containing and co-stimulation members and their signaling pathways, as well as their complicated role in the life and death of cancer cells.

The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.

The tumor necrosis factor (TNF) superfamily, composed of 19 ligands and 29 receptors, plays highly diversified roles in the body.

The tumor necrosis factor (TNF) ligand and cognate TNF receptor superfamilies constitute an important regulatory axis that is pivotal for immune homeostasis and correct execution of immune responses.

The Tumor Necrosis Factor (TNF) superfamily (TNFSF) comprises TNFSF ligands and their cognate TNF receptor superfamily (TNFRSF) members. TNFSFs are essential for innate and adaptive immunity and are implicated in diverse pathological conditions such as autoimmune diseases, developmental abnormalities, and cancer ( 1 , 2 ).

2018年1月2日 · The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling pathways is expected to have therapeutic benefit for patients with various diseases, including cancer, autoimmunity …

Tumor necrosis factor (TNF) superfamily pathways regulate cell proliferation, cell death, and morphogenesis. TNF superfamily receptors mediate various cancers and immune-mediated diseases.

The tumor necrosis factor (TNF) superfamily consists of members that are distantly related to TNF and have important functions in the regulation of immune responses, inflammation, and tissue homeostasis.

2017年8月10日 · TNF Superfamily Basics: Membrane Bound Ligands and Three Receptor Types. The ligands are typically membrane bound, although some can signal as soluble species as well. The ligands also self-assemble into non-covalent trimeric complexes.