The Von Hippel–Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. Mutations of the VHL gene are associated with Von Hippel–Lindau disease , which is characterized by hemangioblastomas of the brain, spinal cord and retina.

2024年12月25日 · VHL (Von Hippel-Lindau Tumor Suppressor) is a Protein Coding gene. Diseases associated with VHL include Von Hippel-Lindau Syndrome and Erythrocytosis, Familial, 2. Among its related pathways are Class I MHC mediated antigen processing and presentation and Replication of the SARS-CoV-1 genome.

2014年12月23日 · VHL tumour suppressor protein (pVHL) plays a key part in cellular oxygen sensing by targeting hypoxia-inducible factors for ubiquitylation and proteasomal degradation.

The VHL gene provides instructions for making a protein that functions as part of a complex (a group of proteins that work together) called the VCB-CUL2 complex. This complex targets other proteins to be broken down (degraded) by the cell when they are no longer needed.

von Hippel-Lindau (VHL) protein (pVHL) is a ciliary protein that controls ciliogenesis in kidney cells. VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation

Jung Y.S., Lee S.J., Yoon M.H., Ha N.C., Park B.J. Estrogen receptor α is a novel target of the Von Hippel-Lindau protein and is responsible for the proliferation of VHL-deficient cells under hypoxic conditions.

The von Hippel-Lindau tumor suppressor gene (VHL) encodes a multifunctional protein, the mutations of which underlie the genetic defect in the familial VHL disease.

Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Cancer Res. 2004;64:1278–86. doi: 10.1158/0008-5472.can-03-0884.

2011年9月26日 · The VHL protein is best known as an E3 ubiquitin ligase that targets hypoxia-inducible factor-α (HIF-α), but many diverse, non-canonical cellular functions have also been assigned to VHL,...

The Von Hippel-Lindau (VHL) protein is a tumor suppressor that functions as a subunit of a multiprotein ubiquitin ligase. It negatively regulates the expression of hypoxia-inducible genes by targeting hypoxia-inducible transcription factors (HIFs) for degradation.