Xist RNA in action: Past, present, and future - PMC
Xist RNA is the master regulator of X-chromosome inactivation (XCI), the epigenetic process that equalizes the dosage of X-linked genes between female (XX) and male (XY) mammals.
XIST RNA Gene - GeneCards
2024年12月25日 · XIST (X Inactive Specific Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with XIST include X Inactivation, Familial Skewed, 1 and …
XIST RNA and Architecture of the Inactive X chromosome: …
XIST RNA paints and induces silencing of one X chromosome in mammalian female cells, providing a powerful model to investigate long-range chromosomal regulation. This review …
Xist localization and function: new insights from multiple levels
2015年8月15日 · Xist encodes a 17-kb long non-coding RNA (lncRNA) that, despite being capped, spliced and poly-adenylated, is retained in the nucleus. In mouse, XCI occurs in two …
Xist RNA and the mechanism of X chromosome inactivation
Xist encodes an RNA molecule that plays critical roles in the choice of which X chromosome remains active, and in the initial spread and establishment of silencing on the inactive X …
Function by Structure: Spotlights on Xist Long Non-coding RNA
Xist, the master regulator of X chromosome inactivation, is a classic example of how lncRNAs can exert multi-layered and fine-tuned regulatory functions, by acting as a molecular scaffold for …
Xist RNA in action: Past, present, and future | PLOS Genetics
2019年9月19日 · Xist RNA is the master regulator of X-chromosome inactivation (XCI), the epigenetic process that equalizes the dosage of X-linked genes between female (XX) and …
Progress toward understanding chromosome silencing by Xist RNA
2020年6月1日 · The X inactive-specific transcript ( Xist ) gene is the master regulator of X chromosome inactivation in mammals. Xist produces a long noncoding (lnc)RNA that …
XIST RNA: a window into the broader role of RNA in nuclear
2017年11月5日 · XIST RNA triggers the transformation of an active X chromosome into a condensed, inactive Barr body and therefore provides a unique window into transitions of …
Targeting Xist with compounds that disrupt RNA structure and X ...
2022年3月30日 · Here we devise a screening strategy and identify small molecules that bind the non-coding RNA prototype Xist 5. The X1 compound has drug-like properties and binds …
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