Xist RNA is the master regulator of X-chromosome inactivation (XCI), the epigenetic process that equalizes the dosage of X-linked genes between female (XX) and male (XY) mammals.

Dec 25, 2024 · XIST (X Inactive Specific Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with XIST include X Inactivation, Familial Skewed, 1 and …

XIST RNA paints and induces silencing of one X chromosome in mammalian female cells, providing a powerful model to investigate long-range chromosomal regulation. This review …

Aug 15, 2015 · Xist encodes a 17-kb long non-coding RNA (lncRNA) that, despite being capped, spliced and poly-adenylated, is retained in the nucleus. In mouse, XCI occurs in two different …

Xist encodes an RNA molecule that plays critical roles in the choice of which X chromosome remains active, and in the initial spread and establishment of silencing on the inactive X …

Xist, the master regulator of X chromosome inactivation, is a classic example of how lncRNAs can exert multi-layered and fine-tuned regulatory functions, by acting as a molecular scaffold for …

Sep 19, 2019 · Xist RNA is the master regulator of X-chromosome inactivation (XCI), the epigenetic process that equalizes the dosage of X-linked genes between female (XX) and …

Jun 1, 2020 · The X inactive-specific transcript ( Xist ) gene is the master regulator of X chromosome inactivation in mammals. Xist produces a long noncoding (lnc)RNA that …

Nov 5, 2017 · XIST RNA triggers the transformation of an active X chromosome into a condensed, inactive Barr body and therefore provides a unique window into transitions of higher-order …

Mar 30, 2022 · Here we devise a screening strategy and identify small molecules that bind the non-coding RNA prototype Xist 5. The X1 compound has drug-like properties and binds …