This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell–cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.

ZO-1 was the first tight junction protein to be discovered. 22 It is a cytosolic peripheral membrane protein with multiple domains specialized for protein interactions. Among these are three PDZ (PSD95/Dlg/ZO-1) domains, a Src homology-3 (SH3) domain, …

2024年12月25日 · TJP1 (Tight Junction Protein 1) is a Protein Coding gene. Diseases associated with TJP1 include Arrhythmogenic Right Ventricular Cardiomyopathy and Brain Edema. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Gene expression (Transcription).

ZO-1 makes critical, tight junction-independent contributions to Wnt signaling and mitotic spindle orientation. As a result, ZO-1 is essential for mucosal repair. We speculate that ZO-1 down-regulation may be one cause of ineffective mucosal healing in patients with IBD.

In vitro and in vivo studies have linked downregulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction permeability. This has not, however, been tested in vivo. Here, we assessed the contributions of ZO-1 to …

1998年11月6日 · To further elucidate the role of ZO-1 within the epithelial tight junction, we have introduced epitope-tagged fragments of ZO-1 into cultured MDCK cells and identified domains critical for the interaction with ZO-2, occludin, and F-actin.

2024年5月23日 · Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions...

Zonula occludens‐1 (ZO‐1) is a scaffolding protein of tight junctions, which seal adjacent epithelial cells, that is also expressed in adherens junctions. The distribution pattern of ZO‐1 differs among stratified squamous epithelia, including that between skin and oral buccal mucosa.

2021年9月25日 · Previous studies have identified that ZO-1 localizes to the nucleus during proliferation, while it also cytoplasmically sequesters the ZO-1–associated nucleic acid binding protein (ZONAB), a Y-box transcription factor whose nuclear localization and transcriptional activity increase epithelial proliferation. 8, 9 This indicates that ZO-1 at ...

2021年7月22日 · We found consistent down-regulation of the tight junction scaffolding protein zonula occludens-1 (ZO-1) and confirmed this immunohistochemically.