Epithelial surfaces are more than simple physical obstructions; they constitute complex chemical and biological obstacles. The acidity of the stomach and the mucus lining, as well as microbicidal enzymes in the gastrointestinal tract are often sufficient to prevent microbial invasion.

2014年2月25日 · Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. Secretory IECs support...

The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier.

The mucus layer and the intestinal epithelial cells represent the main determinants of the physical intestinal barrier and have a fundamental role in health. Various methods are available to evaluate the function of the intestinal barrier, but correlation of results across studies and methodologies remains difficult.

2018年8月16日 · Epithelial cells form a layer that functions as a physical barrier facilitated by tight connections between each cell. A number of tight junction protein components seal the paracellular pathway...

2023年11月1日 · The epithelial barrier serves as the body's primary physical, chemical, and immunological barrier against external stimuli. A leaky epithelial barrier facilitates the translocation of the microbiome from the surface of the afflicted tissues to interepithelial and even deeper subepithelial locations.

2015年1月1日 · Using the intestinal epithelium as an example, this chapter explores the regulation of epithelial barrier function in physiological and pathophysiological conditions and the intersection between intestinal paracellular permeability and mucosal immunity.

2016年11月16日 · Here, we review and discuss mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases. We conclude...

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as the intestinal microbiota, the underlying immune system and the remainder of the body, while supporting vectorial transport of …

It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases, can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria.